Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Introduction: The second messengers cAMP and cGMP mediate fundamental aspects of
brain function relevant to memory, learning, and cognitive functions. Consequently, cyclic …

Chronic degenerative inflammatory diseases, such as chronic obstructive pulmonary
disease and Alzheimer's dementia, afflict millions of people around the world, causing death …

Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates signal
transduction pathways pivotal for numerous biological functions. Intracellular cAMP levels …

Recent evidence suggests that schizophrenia may result from alterations of integration of
signaling mediated by multiple neurotransmitter systems. Abnormalities of associated …

Activity-dependent structural plasticity at the synapse requires specific changes in the
neuronal transcriptome. While much is known about the role of coding elements in this …

It has now been over 10 years since efforts to completely understand the signalling actions
of cAMP (3′‐5′‐cyclic adenosine monophosphate) led to the discovery of exchange …

Dynamic remodeling of spiny synapses is crucial for cortical circuit development, refinement
and plasticity, whereas abnormal morphogenesis is associated with neuropsychiatric …