Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

The deposition of chemical modifications into RNA is a crucial regulator of temporal and
spatial gene expression programs during development. Accordingly, altered RNA …

Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic
information organized in mRNA codons, translating them into the code of 20 amino acids. To …

Tumor progression is associated with dedifferentiated histopathologies concomitant with
cancer cell survival within a changing, and often hostile, tumor microenvironment. These …

Transfer RNA (tRNA) plays a central role in translation by functioning as a biological link
between messenger RNA (mRNA) and proteins. One prominent feature of the tRNA …

Macrophage polarization is a process whereby macrophages acquire distinct effector states
(M1 or M2) to carry out multiple and sometimes opposite functions. We show here that …

The pool of transfer RNA (tRNA) molecules in cells allows the ribosome to decode genetic
information. This repertoire of molecular decoders is positioned in the crossroad of the …

A remarkable number of neurodevelopmental disorders have been linked to defects in tRNA
modifications. These discoveries place tRNA modifications in the spotlight as critical …

A key characteristic of cancer cells is their increased proliferative capacity, which requires
elevated levels of protein synthesis. The process of protein synthesis involves the translation …