Learning dynamical models of single and collective cell migration: a review

D Brückner, CP Broedersz - Reports on Progress in Physics, 2024 - iopscience.iop.org
Single and collective cell migration are fundamental processes critical for physiological
phenomena ranging from embryonic development and immune response to wound healing …

Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models

DB Brückner, E Hannezo - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
The importance of physical forces in the morphogenesis, homeostatic function, and
pathological dysfunction of multicellular tissues is being increasingly characterized, both …

Coordinated motion of epithelial layers on curved surfaces

L Happel, A Voigt - Physical Review Letters, 2024 - APS
Coordinated cellular movements are key processes in tissue morphogenesis. Using a cell-
based modeling approach we study the dynamics of epithelial layers lining surfaces with …

Geometry adaptation of protrusion and polarity dynamics in confined cell migration

DB Brückner, M Schmitt, A Fink, G Ladurner… - Physical Review X, 2022 - APS
Cell migration in confining physiological environments relies on the concerted dynamics of
several cellular components, including protrusions, adhesions with the environment, and the …

How multiscale curvature couples forces to cellular functions

M Luciano, C Tomba, A Roux, S Gabriele - Nature Reviews Physics, 2024 - nature.com
Among the physicochemical cues in the cellular microenvironment that orchestrate cell
processes, the different levels of curvature in the extracellular matrix and intrinsic to the …

Polarization and motility of one-dimensional multi-cellular trains

JE Ron, J d'Alessandro, V Cellerin, R Voituriez… - Biophysical …, 2023 - cell.com
Collective cell migration, whereby cells adhere to form multi-cellular clusters that move as a
single entity, play an important role in numerous biological processes, such as during …

A Vicsek-type model of confined cancer cells with variable clustering affinities

Z Kirchner, A Geohagan, A Truszkowska - Integrative Biology, 2024 - academic.oup.com
Clustering of cells is an essential component of many biological processes from tissue
formation to cancer metastasis. We develop a minimal, Vicsek-based model of cellular …

The Mechanics of Building Functional Organs

TGR Andrews, R Priya - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Organ morphogenesis is multifaceted, multiscale, and fundamentally a robust process.
Despite the complex and dynamic nature of embryonic development, organs are built with …

Mesenchymal cell migration on one-dimensional micropatterns

JCJ Heyn, JO Rädler, M Falcke - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Quantitative studies of mesenchymal cell motion are important to elucidate cytoskeleton
function and mechanisms of cell migration. To this end, confinement of cell motion to one …