[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Cannabis, the Endocannabinoid System and Immunity—the Journey from the Bedside to the Bench and Back

O Almogi-Hazan, R Or - International journal of molecular sciences, 2020 - mdpi.com
The Cannabis plant contains numerous components, including cannabinoids and other
active molecules. The phyto-cannabinoid activity is mediated by the endocannabinoid …

Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol

P Alves, C Amaral, N Teixeira… - Pharmacological …, 2020 - Elsevier
Cannabis is the most used illicit drug worldwide and its medicinal use is under discussion,
being regulated in several countries. However, the psychotropic effects of Δ 9 …

Peroxisome proliferator-activated receptors: Experimental targeting for the treatment of inflammatory bowel diseases

J Decara, P Rivera, AJ López-Gambero… - Frontiers in …, 2020 - frontiersin.org
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor
proteins that promote ligand-dependent transcription of target genes that regulate energy …

A guide to targeting the endocannabinoid system in drug design

A Stasiulewicz, K Znajdek, M Grudzień… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …

Cannabidiol (CBD) in cancer management

K O'Brien - Cancers, 2022 - mdpi.com
Simple Summary Cannabidiol (CBD) is one of the main constituents of the plant Cannabis
sativa. Surveys suggest that medicinal cannabis is popular amongst people diagnosed with …

Endocannabinoid system as a promising therapeutic target in inflammatory bowel disease–a systematic review

S Hryhorowicz, M Kaczmarek-Ryś, A Zielińska… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is a general term used to describe a group of chronic
inflammatory conditions of the gastrointestinal tract of unknown etiology, including two …

Endocannabinoid system: chemical characteristics and biological activity

B Rezende, AKN Alencar, GF de Bem… - Pharmaceuticals, 2023 - mdpi.com
The endocannabinoid system (eCB) has been studied to identify the molecular structures
present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands …

Fat of the gut: epithelial phospholipids in inflammatory bowel diseases

LV Boldyreva, MV Morozova, SS Saydakova… - International journal of …, 2021 - mdpi.com
Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant …

[HTML][HTML] Role of the endocannabinoid system in the regulation of intestinal homeostasis

H Cuddihey, WK MacNaughton, KA Sharkey - Cellular and molecular …, 2022 - Elsevier
The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal
barrier function and immune regulation are key determinants of intestinal homeostasis and …