Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Background MYD88 L265P and CXCR4WHIM mutations are highly prevalent in
Waldenström's macroglobulinemia. MYD88L265P triggers tumor-cell growth through …

Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-
coupled seven-span transmembrane receptors, are major regulators of cell trafficking and …

The genetic basis for Waldenström macroglobulinemia (WM) remains to be clarified.
Although 6q losses are commonly present, recurring gene losses in this region remain to be …

Whole genome sequencing has revealed activating somatic mutations in MYD88 (L265P)
and CXCR4 in Waldenström macroglobulinemia (WM). CXCR4 somatic mutations in WM …

Aberrant production of autoantibodies by inappropriately self-reactive plasma cells is an
inherent characteristic of autoimmune diseases. Several therapeutic strategies aim to …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

Waldenström macroglobulinemia (WM) is a distinct B-cell lymphoproliferative disorder for
which clearly defined criteria for the diagnosis, initiation of therapy, and treatment strategy …

Purpose: Responses to therapy with chimeric antigen receptor T cells recognizing CD19
(CART19, CTL019) may vary by histology. Mantle cell lymphoma (MCL) represents a B-cell …