Subversion of niche-signalling pathways in colorectal cancer: what makes and breaks the intestinal stem cell
N Sphyris, MC Hodder, OJ Sansom - Cancers, 2021 - mdpi.com
Simple Summary The intestinal epithelium—a single-cell layer lining the luminal surface of
the small and large intestine—comprises an array of highly specialized cell types that …
the small and large intestine—comprises an array of highly specialized cell types that …
GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis
Y Pu, Y Song, M Zhang, C Long, J Li, Y Wang… - … and Targeted Therapy, 2021 - nature.com
Intestinal epithelium serves as the first barrier against the infections and injuries that mediate
colonic inflammation. Colorectal cancer is often accompanied with chronic inflammation …
colonic inflammation. Colorectal cancer is often accompanied with chronic inflammation …
Integrin α5 subunit is required for the tumor supportive role of fibroblasts in colorectal adenocarcinoma and serves as a potential stroma prognostic marker
The tumorigenesis of colorectal cancer (CRC) is a complicated process, involving
interactions between cancer cells and the microenvironment. The role of α5 integrin subunit …
interactions between cancer cells and the microenvironment. The role of α5 integrin subunit …
Oral exposure to high concentrations of polystyrene microplastics alters the intestinal environment and metabolic outcomes in mice
Y Hasegawa, T Okamura, Y Ono, T Ichikawa… - Frontiers in …, 2024 - frontiersin.org
Introduction Oral exposure to microplastics (MPs) is a global health concern. In our previous
study, MPs induced glucose intolerance and non-alcoholic fatty liver disease (NAFLD) under …
study, MPs induced glucose intolerance and non-alcoholic fatty liver disease (NAFLD) under …
Notch1 cortical signaling regulates epithelial architecture and cell–cell adhesion
MJ White, KA Jacobs, T Singh, LN Mayo, A Lin… - Journal of Cell …, 2023 - rupress.org
Notch receptors control tissue morphogenic processes that involve coordinated changes in
cell architecture and gene expression, but how a single receptor can produce these diverse …
cell architecture and gene expression, but how a single receptor can produce these diverse …
The potential oncogenic effect of tissue-specific expression of JC polyoma T antigen in digestive epithelial cells
H Zheng, H Xue, H Sun, W Yun, Z Cui - Transgenic Research, 2023 - Springer
JC polyoma virus (JCPyV), a ubiquitous polyoma virus that commonly infects people, is
identified as the etiologic factor for progressive multifocal leukoencephalopathy and has …
identified as the etiologic factor for progressive multifocal leukoencephalopathy and has …
[HTML][HTML] Expression and clinical significance of Numb and Notch-1 proteins between tissue of colon cancer and regional lymph node metastases
J Ma, J Zhen, N Yang, C Meng, Y Lian - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Objective To investigate the expression and clinical significance of Notch-1 and Numb
protein in colon cancer tissues and regional lymph node metastases. Methods …
protein in colon cancer tissues and regional lymph node metastases. Methods …
Targeting of Notch, IL-1, and leptin has therapeutic potential in xenograft colorectal cancer
Background/aim: Colorectal cancer (CRC) is a fatal malignancy type and its occurence still
needs to be explored mechanistically. Notch, IL-1, and leptin crosstalk is reported to play a …
needs to be explored mechanistically. Notch, IL-1, and leptin crosstalk is reported to play a …
De novo Assembly and Analysis of Tissue-Specific Transcriptomes of the Edible Red Sea Urchin Loxechinus albus Using RNA-Seq
Simple Summary Edible red sea urchin (Loxechinus albus) is an endemic species of
echinoderm distributed along the Chilean coasts. This resource has been overexploited in …
echinoderm distributed along the Chilean coasts. This resource has been overexploited in …
The oncogenic roles of John Cunningham virus T antigen in digestive epithelial cells with tissue specificity
H Zheng, H Xue, E Ying, Z Cui - 2022 - researchsquare.com
Background John Cunningham virus (JCV), a ubiquitous polyoma virus that commonly
infects the human, is identified as the etiologic factor for progressive multifocal …
infects the human, is identified as the etiologic factor for progressive multifocal …