The epithelial–mesenchymal transition (EMT) is a developmental process that is important
for embryogenesis, wound healing, organ fibrosis, and cancer metastasis. Cancer …

The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is
inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell …

Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in
reprogramming. To uncover pathways that maintain cell identity, we performed a …

The chromatin regulator FACT (facilitates chromatin transcription) is essential for ensuring
stable gene expression by promoting transcription. In a genetic screen using Caenorhabditis …

Abstract Derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming somatic
cells to a pluripotent state has revolutionized stem cell research. Ensuing this, various …

Human umbilical cord-derived mesenchymal stem cells (hucMSCs) are suggested as a
promising therapeutic tool in regenerative medicine, however, their efficacy requires …

Acute as well as chronic disorders of the nervous system lead to significant morbidity and
mortality for millions of individuals globally. Given the ability to govern stem cell proliferation …

As the world's population continues to age, it is estimated that degenerative joint disease
disorders such as osteoarthritis will impact at least 130 million individuals throughout the …

As a proliferative and restorative entity, Wnt1 inducible signaling pathway protein 1 (WISP1)
is emerging as a novel target for a number of therapeutic strategies that are relevant for …