The large and functionally diverse group of G-protein-coupled receptors includes receptors
for many different signalling molecules, including peptide and non-peptide hormones and …

Direct structural data on receptors coupled to G proteins were obtained last year in the form
of a low resolution projection map of rhodopsin. A large number of receptor sequences have …

G-protein-coupled receptors (GPCRs) constitute one of the largest protein families in the
human genome. They are subject to numerous post-translational modifications, including …

Mislocalization of the photopigment rhodopsin may be involved in the pathology of certain
inherited retinal degenerative diseases. Here, we have elucidated rhodopsin's targeting …

Guanine nucleotide binding protein (G protein)-linked receptors, the α-sub-units of
heterotrimeric G proteins and members of the Src family of non-receptor tyrosine kinases are …

Signal transduction via G-protein-coupled receptors (GPCRs) is a fundamental pathway
through which the functions of an individual cell can be integrated within the demands of a …

The three α2-adrenergic receptor (α2AR) subtypes, all of which couple to multiple effectors
via Gi/Go proteins, perform various functions, including the mediation of decreases in …

GRK6, a 66-kDa serine/threonine protein kinase, is a recently identified member of the G
protein-coupled receptor kinase (GRK) family. GRKs are involved in the phosphorylation of …

Excessive uptake of fatty acids and glucose by adipose tissue triggers adipocyte dysfunction
and infiltration of immune cells. Altered metabolic homeostasis in adipose tissue promotes …

By site-directed mutagenesis, three cysteine residues (amino acids 402, 403, and 405) in
the carboxyl terminus of human endothelin B (ET B) were identified as potential …