T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy
characterized by aberrant proliferation of immature thymocytes. Despite an overall survival …

Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a
parent drug in the body. In the past, prodrugs were used as a last option; however …

AKR1C3 is an enzyme belonging to the aldo-ketoreductase family, the members of which
catalyze redox transformations involved in biosynthesis, intermediary metabolism, and …

Human aldo-keto reductase family 1 member C3 (AKR1C3) is known as a hormone activity
regulator and prostaglandin F (PGF) synthase that regulates the occupancy of hormone …

* Disease status and patients' characteristics evaluated at the time of starting daratumumab
therapy. Includes the patient in complete remission with isolated measurable residual …

Abstract Aldo-keto reductase 1C3 (AKR1C3) is overexpressed in multiple hormone related
cancers, such as breast and prostate cancer, and is correlated with tumor development and …

AKR1C3 is an enzyme that is overexpressed in several types of radiotherapy-and
chemotherapy-resistant cancers. Despite AKR1C3 is a validated target for drug …

The KEAP1‐NRF2 pathway regulates the main inducible cellular response to oxidative and
electrophilic stresses. Activating mutations in the KEAP1‐NRF2 pathway occur commonly in …

The microenvironment that surrounds a tumor, in addition to the tumor itself, plays an
important role in the onset of resistance to molecularly targeted therapies. Cancer cells and …

Simple Summary The multidrug resistance of EAC is one of the major obstacles to
chemotherapeutic efficiency. Our study aims to explore the molecular mechanism of …