Extracellular metabolism sets the table for microbial cross-feeding

RK Fritts, AL McCully, JB McKinlay - Microbiology and Molecular …, 2021 - Am Soc Microbiol
The transfer of nutrients between cells, or cross-feeding, is a ubiquitous feature of microbial
communities with emergent properties that influence our health and orchestrate global …

Data-driven causal analysis of observational biological time series

AE Yuan, W Shou - Elife, 2022 - elifesciences.org
Complex systems are challenging to understand, especially when they defy manipulative
experiments for practical or ethical reasons. Several fields have developed parallel …

The microbial exometabolome: ecological resource and architect of microbial communities

AE Douglas - … Transactions of the Royal Society B, 2020 - royalsocietypublishing.org
All microorganisms release many metabolites, collectively known as the exometabolome.
The resultant multi-way cross-feeding of metabolites among microorganisms distributes …

Response of sugarcane rhizosphere bacterial community to drought stress

Q Liu, X Zhao, Y Liu, S Xie, Y Xing, J Dao… - Frontiers in …, 2021 - frontiersin.org
Sugarcane is an important sugar and energy crop, and its yield is greatly affected by
drought. Although a large number of studies have shown that rhizosphere microorganisms …

Simulations reveal challenges to artificial community selection and possible strategies for success

L Xie, AE Yuan, W Shou - PLoS biology, 2019 - journals.plos.org
Multispecies microbial communities often display “community functions” arising from
interactions of member species. Interactions are often difficult to decipher, making it …

Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions

SFM Hart, CC Chen, W Shou - Elife, 2021 - elifesciences.org
Cooperation, paying a cost to benefit others, is widespread. Cooperation can be promoted
by pleiotropic 'win-win'mutations which directly benefit self (self-serving) and partner (partner …

Emergence and maintenance of stable coexistence during a long-term multicellular evolution experiment

RM Pineau, E Libby, D Demory, DT Lac… - Nature ecology & …, 2024 - nature.com
The evolution of multicellular life spurred evolutionary radiations, fundamentally changing
many of Earth's ecosystems. Yet little is known about how early steps in the evolution of …

Enhanced nutrient uptake is sufficient to drive emergent cross-feeding between bacteria in a synthetic community

RK Fritts, JT Bird, MG Behringer, A Lipzen… - The ISME …, 2020 - academic.oup.com
Interactive microbial communities are ubiquitous, influencing biogeochemical cycles and
host health. One widespread interaction is nutrient exchange, or cross-feeding, wherein …

Metabolic excretion associated with nutrient–growth dysregulation promotes the rapid evolution of an overt metabolic defect

R Green, Sonal, L Wang, SFM Hart, W Lu… - PLoS …, 2020 - journals.plos.org
In eukaryotes, conserved mechanisms ensure that cell growth is coordinated with nutrient
availability. Overactive growth during nutrient limitation (“nutrient–growth dysregulation”) can …

Systematic dissection of a complex gut bacterial community

AG Cheng, A Aranda-Díaz, S Jain, F Yu, M Iakiviak… - bioRxiv, 2021 - biorxiv.org
Efforts to model the gut microbiome have yielded important insights into the mechanisms of
interspecies interactions, the impact of priority effects on ecosystem dynamics, and the role …