CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that
protects against viral infection by targeting specific invading nucleic acid sequences …

In prokaryotes, CRISPR-Cas immune systems recognize and cleave foreign nucleic acids to
defend against mobile genetic elements (MGEs). Type III CRISPR-Cas complexes also …

CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-
associated) systems are adaptive immune systems that protect bacteria and archaea from …

To combat phage infection, type III CRISPR-Cas systems utilize cyclic oligoadenylates (cA n)
signaling to activate various auxiliary effectors, including the CRISPR-associated Lon …

Csa3 family transcription factors are ancillary CRISPR-associated proteins composed of N-
terminal CARF domains and C-terminal winged helix-turn-helix domains. The activity of …

In the type III CRISPR system, cyclic oligoadenylate (cOA) molecules act as second
messengers, activating various promiscuous ancillary nucleases that indiscriminately …

Type III CRISPR systems are innate immune systems found in bacteria and archaea, which
produce cyclic oligoadenylate (cOA) second messengers in response to viral infections. In …

The cpdB gene is pro-virulent in avian pathogenic Escherichia coli and in Salmonella
enterica, where it encodes a periplasmic protein named CpdB. It is structurally related to cell …

Type III CRISPR-Cas systems, which are widespread in both bacteria and archaea, provide
immunity against DNA viruses and plasmids in a transcription-dependent manner. Since an …

Type III CRISPR-Cas systems show the target (tg) RNA-activated indiscriminate DNA
cleavage and synthesis of oligoadenylates (cOA) and a secondary signal that activates …