Replication compartments of eukaryotic and bacterial DNA viruses: common themes between different domains of host cells

DM Knipe, A Prichard, S Sharma… - Annual review of …, 2022 - annualreviews.org
Subcellular organization is essential for life. Cells organize their functions into organelles to
concentrate their machinery and supplies for optimal efficiency. Likewise, viruses organize …

The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in …

V Norris, C Kayser, G Muskhelishvili… - FEMS Microbiology …, 2023 - academic.oup.com
How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

[HTML][HTML] Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY

A Prichard, J Lee, TG Laughlin, A Lee, KP Thomas… - Cell reports, 2023 - cell.com
We recently discovered that some bacteriophages establish a nucleus-like replication
compartment (phage nucleus), but the core genes that define nucleus-based phage …

Subcellular organization of viral particles during maturation of nucleus-forming jumbo phage

V Chaikeeratisak, K Khanna, KT Nguyen… - Science …, 2022 - science.org
Many eukaryotic viruses assemble mature particles within distinct subcellular compartments,
but bacteriophages are generally assumed to assemble randomly throughout the host cell …

Phage-induced bacterial morphological changes reveal a phage-derived antimicrobial affecting cell wall integrity

T Soonthonsrima, HH Htoo, P Thiennimitr… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
In a looming post-antibiotic era, antibiotic alternatives have become key players in the
combat against pathogens. Although recent advances in genomic research allow scientists …

The intricate organizational strategy of nucleus-forming phages

A Prichard, J Pogliano - Current Opinion in Microbiology, 2024 - Elsevier
Nucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating
intricate structures for viral replication. Research on this newly appreciated family of phages …

DNA nanotechnology enhanced single-molecule biosensing and imaging

S Fu, T Zhang, H Jiang, Y Xu, J Chen, L Zhang… - TrAC Trends in Analytical …, 2021 - Elsevier
Single-molecule tools enable translating biorecognition events into electrical and optical
signals at the single-molecule level. However, the limitations such as poor specificity, low …

[HTML][HTML] Dye disaggregation light-up aptamer for super-resolution RNA imaging

C Yan, L Miao, Y Zhang, X Zhou, G Wang, Y Li… - Sensors and Actuators B …, 2023 - Elsevier
Genetically encoded light-up RNA aptamers have become powerful tools for visualizing
RNAs in cells. However, fluorogenic dye/aptamer pairs used for super-resolution RNA …

Inhibition of Mitochondrial ATP Synthesis and Regulation of Oxidative Stress Based on {SbW8O30} Determined by Single‐Cell Proteomics Analysis

L Gong, W Ding, Y Chen, K Yu, C Guo… - Angewandte Chemie …, 2021 - Wiley Online Library
The 10‐nuclear heteroatom cluster modified {SbW8O30} was successfully synthesized and
exhibited inhibitory activity (IC50= 0.29 μM). Based on proteomics analysis, Na4Ni2Sb2W2 …

Bacteriophage lambda site‐specific recombination

GD Van Duyne, A Landy - Molecular microbiology, 2024 - Wiley Online Library
The site‐specific recombination pathway of bacteriophage λ encompasses isoenergetic but
highly directional and tightly regulated integrative and excisive reactions that integrate and …