Adeno-associated virus (AAV) has a single-stranded DNA genome encapsidated in a small
icosahedrally symmetric protein shell with 60 subunits. AAV is the leading delivery vector in …

Since their discovery as a tool for gene transfer, vectors derived from the adeno-associated
virus (AAV) have been used for gene therapy applications and attracted scientist to this field …

Gene therapy holds promise for patients with inherited monogenic disorders, cancer, and
rare genetic diseases. Naturally occurring adeno-associated virus (AAV) offers a well-suited …

Highlights•Ad vectors are highly immunogenic and thus superb vaccine carriers.•Most AAVs
are poorly immunogenic and thus more suited for gene replacement therapy.•Pre-existing …

Recombinant adeno-associated viral vectors (rAAV) represent a gene therapy tool of ever-
increasing importance. Their utilization as a delivery vehicle for gene replacement, silencing …

The SARS-CoV-2 pandemic has affected more than 185 million people worldwide resulting
in over 4 million deaths. To contain the pandemic, there is a continued need for safe …

Abstract Parainfluenza virus 5 (PIV5) is a negative‐sense, single‐stranded RNA virus that
can infect humans and many species of animals. Infection in these reservoir hosts is …

An overall decrease of HIV prevalence is now observed in several key Asian countries due
to effective prevention programs. The decrease in HIV prevalence and incidence may further …

Future efficacy trials will focus on prevention of HIV-1 transmission in heterosexual
population in Africa and MSM in Asia. The recent successes leading to novel directions in …

Study Design A randomized, double-blind, placebo controlled phase I trial. Methods The trial
was conducted in 32 HIV-uninfected healthy volunteers to assess the safety and …