Developmental timing and critical windows for the treatment of psychiatric disorders
O Marín - Nature medicine, 2016 - nature.com
There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …
insults during sensitive periods in brain development have long-term consequences on …
How genome-wide association studies (GWAS) made traditional candidate gene studies obsolete
A common belief among statistical geneticists is that genomewide association studies
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …
Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
How effective are cognitive behavior therapies for major depression and anxiety disorders? A meta‐analytic update of the evidence
We report the current best estimate of the effects of cognitive behavior therapy (CBT) in the
treatment of major depression (MDD), generalized anxiety disorder (GAD), panic disorder …
treatment of major depression (MDD), generalized anxiety disorder (GAD), panic disorder …
Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia
By meta-analyzing the whole-exomes of 24,248 cases and 97,322 controls, we implicate
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …
A copy number variation morbidity map of developmental delay
To understand the genetic heterogeneity underlying developmental delay, we compared
copy number variants (CNVs) in 15,767 children with intellectual disability and various …
copy number variants (CNVs) in 15,767 children with intellectual disability and various …
CNVs: harbingers of a rare variant revolution in psychiatric genetics
D Malhotra, J Sebat - Cell, 2012 - cell.com
The genetic bases of neuropsychiatric disorders are beginning to yield to scientific inquiry.
Genome-wide studies of copy number variation (CNV) have given rise to a new …
Genome-wide studies of copy number variation (CNV) have given rise to a new …
MicroRNAs in neural development: from master regulators to fine-tuners
M Rajman, G Schratt - Development, 2017 - journals.biologists.com
The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …
Analysis of copy number variations at 15 schizophrenia-associated loci
E Rees, JTR Walters, L Georgieva, AR Isles… - The British Journal of …, 2014 - cambridge.org
BackgroundA number of copy number variants (CNVs) have been suggested as
susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the …
susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the …
Determining the role of microRNAs in psychiatric disorders
Recent studies have revealed that patients with psychiatric disorders have altered
microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal …
microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal …