Introduction The most prevalent biological macromolecules in living systems are proteins,
the building block of life, extremely dynamic in structure and functions. Due to several …

The aggregation and accumulation of amyloidogenic peptides and proteins are observed as
pathological features in the brains of patients suffering from neurodegenerative disorders …

Aberrant protein folding known as protein misfolding is counted as one of the striking factors
of neurodegenerative diseases. The extensive range of pathologies caused by protein …

Conformational conversion of the α-helix-rich cellular prion protein into the misfolded, β-rich,
aggregated, scrapie form underlies the molecular basis of prion diseases that represent a …

Many incurable or unmanageable human protein conformational diseases are associated
with the misfolding or aggregation of the aberrantly processed or mutant proteins. In this …

Prion diseases are fatal brain disorders characterized by deposition of insoluble isoforms of
the prion protein (PrP). The normal and pathogenic structures of PrP are relatively well …

Protein aggregation into amyloid fibrils is the archetype of aberrant biomolecular self-
assembly processes, with more than 50 associated diseases that are mostly uncurable …

Amyloids were conventionally referred to as extracellular and intracellular accumulation of
Aβ42 peptide, which causes the formation of plaques and neurofibrillary tangles inside the …

The Zingiberaceae family possess various phenolic compounds that have significant
systemic bioactivities in the brain, including in age-related neurodegenerative diseases …

Protein expression and function in eukaryotic cells are tightly harmonized processes
modulated by the combination of different layers of regulation, including transcription …