Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very
heterogeneous biological and clinical behavior. The last decade has been remarkably …

Many diseases heal spontaneously. The common cold, for example, remedies itself within a
few days in people with an uncompromised immune system. If a disease with a poor …

Clonal evolution represents the natural process through which cancer cells continuously
search for phenotypic advantages that enable them to develop and expand within …

Background: A recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-
Cov-2), which began in Wuhan, China, with a high level of human-to-human transmission …

Simple Summary The p53 pathway plays a fundamental role in preventing the accumulation
of unrepaired DNA damage. Unsurprisingly, cancer cells often break this protective barrier …

Chronic lymphocytic leukaemia (CLL) is not only characterised by driver genetic alterations
but by extensive epigenetic changes. Over the last decade, epigenomic studies have …

Single-cell analysis has emerged over the past decade as a transformative technology
informative for the systematic analysis of complex cell populations such as in cancers and …

Chronic lymphocytic leukemia (CLL) is characterized by widespread alterations in the
genetic and epigenetic landscapes which seem to underlie the variable clinical …

Thirty-seven patients were alive at the last follow-up, 13 had died (two dementia-related
causes, one pneumonia, one warfarin-related bleeding, one ovarian cancer, eight because …

Minimal residual disease (MRD), a measure of residual cancer cells, is a concept
increasingly employed in precision oncology, touted as a key predictive biomarker to guide …