The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine
acetyltransferases that serve as critical co-activators for transcription factors involved in …

BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …

Abstract Bromodomain‐containing protein 4 (BRD4), as the most studied member of the
bromodomain and extra‐terminal (BET) family, is a chromatin reader protein interpreting …

Simple Summary Breast cancer is the most common cancer in women, affecting 1 in 20
women globally. Breast cancer is divided into four subtypes: luminal A, luminal B, HER2 …

Protein acetylation is a reversible post-translational modification, and is involved in many
biological processes in cells, such as transcriptional regulation, DNA damage repair, and …

Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as
critical drivers of tumorigenesis and therapeutic targets. Characterized by substantial …

Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (HL) share a
similar cytological and high surface expression of CD30, and novel therapeutic strategies …

Adenoviral E1A binding protein p300 (EP300 or p300) and its similar paralog, cyclic-AMP
response element binding protein (CBP), are important histone acetyltransferases (HAT) …

Abnormal epigenetics is a critical hallmark of human cancers. Anticancer drug discovery
directed at histone epigenetic modulators has gained impressive advances with six drugs …