Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain

C Chen, HW Yi, Y Zhang, T Wang, TY Gao, ZL Lou… - bioRxiv, 2023 - biorxiv.org
Ser65-phosphorylated ubiquitin (pUb) was found elevated in neurons of aged and
neurodegenerative brains. Yet little is known whether a causative link exists between pUb …