Alterations in DNA repair pathways are one of the main drivers of cancer insurgence.
Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they …

The neuroprotective effect of the natural antioxidant taxifolin (TAX) is well known for
ischemic pathologies. However, the limitations of taxifolin application are described—poor …

Background The pathological complete response (pCR) to neoadjuvant chemotherapy
(NAC) of breast cancer is closely related to a better prognosis. However, there are no …

Purpose Low expression of HER2 (HER2-low expression) in breast cancer (BC) has unique
biological characteristics. However, whether HER2-low expression has an impact on …

Simple Summary Neoantigens are novel proteins presented on the cell surface and derived
from the accumulation of somatic mutations in tumor cells. They can be recognized by the …

Due to its genetic and phenotypic heterogeneity, breast cancer is very difficult to eliminate.
The harmful consequences of conventional therapies like radiation and chemotherapy have …

Background. MutS homolog 2 (MSH2), with the function of identifying mismatches and
participating in DNA repair, is the “housekeeping gene” in the mismatch repair (MMR) …

Breast cancer has become the most commonly diagnosed cancer. The intra‐and interpatient
heterogeneity induced a considerable variation in treatment efficacy. There is an urgent …

A woman with estrogen/progesterone receptor–positive, ERBB2-negative metastatic breast
cancer developed progressive disease despite treatment with multiple hormonal and …

Breast cancer is the most common malignant tumor in China and even in the world. DNA
repair genes can lead to tumor metastasis by affecting cancer cell resistance. Studies have …