Virtual screening (VS) is an outstanding cornerstone in the drug discovery pipeline. A variety
of computational approaches, which are generally classified as ligand-based (LB) and …

Modulating disease-relevant protein-protein interactions (PPIs) using small-molecule
inhibitors is a quite indispensable diagnostic and therapeutic strategy in averting …

3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …

Abstract “Molecular glue”(MG) is a term coined to describe the mechanism of action of the
plant hormone auxin and subsequently used to characterize synthetic small molecule …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

Structure-based stabilization of protein–protein interactions (PPIs) is a promising strategy for
drug discovery. However, this approach has mainly focused on the stabilization of native …

Small molecules that modulate the 14-3-3 protein–protein interaction (PPI) network
represent valuable therapeutics and tool compounds. However, access has been lost to 14 …

The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy
in chemical biology and drug discovery. The identification of suitable starting points for …

High-diversity genetically-encoded combinatorial libraries (108− 1013 members) are a rich
source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries …

Molecules that stabilize protein–protein interactions (PPIs) are invaluable as tool
compounds for biophysics and (structural) biology, and as starting points for molecular glue …