Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
Host–parasite co-evolution and its genomic signature
Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
The landscape of tolerated genetic variation in humans and primates
H Gao, T Hamp, J Ede, JG Schraiber, J McRae… - Science, 2023 - science.org
Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …
individuals, but our understanding of their clinical relevance remains largely incomplete. To …
The inflated significance of neutral genetic diversity in conservation genetics
JC Teixeira, CD Huber - Proceedings of the National …, 2021 - National Acad Sciences
The current rate of species extinction is rapidly approaching unprecedented highs, and life
on Earth presently faces a sixth mass extinction event driven by anthropogenic activity …
on Earth presently faces a sixth mass extinction event driven by anthropogenic activity …
Natural selection and infectious disease in human populations
EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …
genetic variation in modern populations, and this has important implications for the growing …
Genomic evidence of rapid and stable adaptive oscillations over seasonal time scales in Drosophila
In many species, genomic data have revealed pervasive adaptive evolution indicated by the
fixation of beneficial alleles. However, when selection pressures are highly variable along a …
fixation of beneficial alleles. However, when selection pressures are highly variable along a …
Detection of human adaptation during the past 2000 years
Detection of recent natural selection is a challenging problem in population genetics. Here
we introduce the singleton density score (SDS), a method to infer very recent changes in …
we introduce the singleton density score (SDS), a method to infer very recent changes in …
Balancing selection maintains hyper-divergent haplotypes in Caenorhabditis elegans
Across diverse taxa, selfing species have evolved independently from outcrossing species
thousands of times. The transition from outcrossing to selfing decreases the effective …
thousands of times. The transition from outcrossing to selfing decreases the effective …
Determinants of mutation rate variation in the human germline
L Ségurel, MJ Wyman… - Annual review of genomics …, 2014 - annualreviews.org
Because germline mutations are the source of all evolutionary adaptations and heritable
diseases, characterizing their properties and the rate at which they arise across individuals …
diseases, characterizing their properties and the rate at which they arise across individuals …
Human genetics and malaria resistance
SN Kariuki, TN Williams - Human genetics, 2020 - Springer
Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …
throughout much of the last five thousand years and, as a result, it is the strongest force for …