Signaling pathways regulate contraction of striated (skeletal and cardiac) and smooth
muscle. Although these are similar, there are striking differences in the pathways that can be …

Members of the PGC‐1 family of coactivators have been revealed as key players in the
regulation of energy metabolism. Early gain‐and loss‐of‐function studies led to the …

Although the concept of energy starvation in the failing heart was proposed decades ago,
still very little is known about the origin of energetic failure. Recent advances in molecular …

Protein kinase A (PKA) is a central regulator of cardiac performance and morphology.
Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress …

Heart failure is a pressing public health problem with no curative treatment currently
available. The existing therapies provide symptomatic relief, but are unable to reverse …

The heart is responsible for pumping blood throughout the blood vessels to the periphery by
repeated, rhythmic contractions at variable intensity. As such the heart should permanently …

This review focuses on the evidence accumulated in humans and animal models to the
effect that mitochondria are key players in the progression of heart failure (HF). Mitochondria …

The use of short-term (1–5 days) treadmill running is becoming increasingly common as a
model to study physiological adaptations following the exercise. Although the beneficial …

The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1s (PGC-1s) can
induce the expression of several downstream genes that play pivotal roles in the regulation …

Disclosures: A. Bayes-Genis reported personal fees from Abbott, personal fees from Astra
Zeneca, personal fees from Novartis, personal fees from Vifor, personal fees from …