The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

Abstract Selenocysteine (Sec), the 21st genetically encoded amino acid, is structurally
similar to cysteine (Cys) but with a sulfur to selenium replacement. This small change …

The ability to construct a peptide or protein in a spatio-specific manner is of great interest for
therapeutic and biochemical research. However, the various functional groups present in …

The development of site‐selective chemistry targeting the canonical amino acids enables
the controlled installation of desired functionalities into native peptides and proteins. Such …

Conspectus Selenoproteins are the family of proteins that contain the amino acid
selenocysteine. Many selenoproteins, including glutathione peroxidases and thioredoxin …

Selenium (Se) is an essential micro-element for many organisms, including
Chlamydomonas reinhardtii, and is required in trace amounts. It is obtained from the 21st …

Background Selenium is an essential trace element, and selenocysteine (Sec, U) is its
predominant form in vivo. Proteins that contain Sec are selenoproteins, whose special …

Methods enabling the dechalcogenation of thiols or selenols have been investigated and
developed for a long time in fields of research as diverse as the study of prebiotic chemistry …

Selenoproteins contain the amino acid selenocysteine (Sec) and are found in all domains of
life. The functions of many selenoproteins are poorly understood, partly due to difficulties in …

The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side
chain functions of natural amino acids. Conversely, no structural and biological function has …