Many agents developed for neuroprotective treatment of Parkinson disease (PD) have
shown great promise in the laboratory, but none have translated to positive results in …

Cognitive dysfunction is one of the most typical characteristics in various neurodegenerative
diseases such as Alzheimer's disease and Parkinson's disease (advanced stage). Although …

Statins have been widely used for the treatment of a variety of conditions beyond their
original role in lowering cholesterol. Since statins have relatively few side effects, they have …

Objective: To evaluate the effect of discontinuing statin therapy on incidence of Parkinson
disease (PD) in statin users. Methods: Participants who were free of PD and initiated statin …

Background In addition to their original applications to lowering cholesterol, statins display
multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely …

Statins, cholesterol lowering drugs, have been demonstrated to exert beneficial effects in
other conditions such as primary and progressing neurodegenerative diseases beyond their …

Neuro-inflammation and oxidative stress plays a key role in the pathophysiology of
Parkinson's disease (PD). Studies demonstrated that neuro-inflammation and associated …

Parkinson's disease is accompanied by nonmotor symptoms including cognitive impairment,
which precede the onset of motor symptoms in patients and are regulated by dopamine (DA) …

Elevated levels of cholesterol and its metabolites (oxysterols) have been reported to be
associated not only with several metabolic syndromes, but also become a prognostic risk …

The anti-inflammatory and neuroprotective effects of trans-cinnamaldehyde (TCA) were
investigated on the inflammatory cells and the dopaminergic degeneration in mice. TCA …