The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …

Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs)
produce monocytes during homeostasis and in response to increased demand during …

INTRODUCTION The hematopoietic road map is a compilation of the various lineage
differentiation routes that a stem cell takes to make blood. This program produces greater …

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under
transplantation conditions,. It has been particularly challenging to study dynamic HSC …

Genetic analyses have shaped much of our understanding of cancer. However, it is
becoming increasingly clear that cancer cells display features of normal tissue organization …

Gene regulatory network is a complicated set of interactions between genetic materials,
which dictates how cells develop in living organisms and react to their surrounding …

The formation of red blood cells begins with the differentiation of multipotent haematopoietic
progenitors. Reconstructing the steps of this differentiation represents a general challenge in …

The dynamics of haematopoietic stem cell differentiation and the hierarchy of oligopotent
stem cells in the bone marrow remain controversial. Here we dissect haematopoietic …

Within the bone marrow, stem cells differentiate and give rise to diverse blood cell types and
functions. Currently, hematopoietic progenitors are defined using surface markers combined …