Cardioprotective actions of relaxin

B Martin, G Romero, G Salama - Molecular and Cellular Endocrinology, 2019 - Elsevier
Relaxin is a hormone of pregnancy first discovered for its ability to induce ligament
relaxation in nonpregnant guinea pig and is important for softening of the birth canal during …

Relaxin as an anti-fibrotic treatment: Perspectives, challenges and future directions

CS Samuel, RG Bennett - Biochemical Pharmacology, 2022 - Elsevier
Fibrosis refers to the scarring and hardening of tissues, which results from a failed immune
system-coordinated wound healing response to chronic organ injury and which manifests …

Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

M Hu, Y Wang, L Xu, S An, Y Tang, X Zhou, J Li… - Nature …, 2019 - nature.com
Activated hepatic stellate cell (aHSC)-mediated liver fibrosis is essential to the development
of liver metastasis. Here, we discover intra-hepatic scale-up of relaxin (RLN, an anti-fibrotic …

New therapies for the treatment of heart failure: a summary of recent accomplishments

F Machaj, E Dembowska, J Rosik… - … and clinical risk …, 2019 - Taylor & Francis
Despite continuous efforts to prevent cardiovascular diseases (CVDs), heart failure prevails
as the number one cause of death in developed countries. To properly treat CVDs, scientists …

Cardiorenal syndrome in heart failure with preserved ejection fraction—an under-recognized clinical entity

A Agrawal, M Naranjo, N Kanjanahattakij… - Heart Failure …, 2019 - Springer
Cardiorenal syndrome (CRS) results from the complex and bidirectional interaction between
the failing heart and the kidneys. Limited information exists about the pathophysiology and …

Imbalanced angiogenesis in peripartum cardiomyopathy―diagnostic value of placenta growth factor―

A Mebazaa, MF Seronde, E Gayat, K Tibazarwa… - Circulation …, 2017 - jstage.jst.go.jp
Background: Concentrations of the anti-angiogenic factor soluble fms-like tyrosine kinase-1
(sFlt-1) are altered in peripartum cardiomyopathy (PPCM). In this study we investigated …

[HTML][HTML] Cellular delivery of relaxin-2 mRNA as a potential treatment for kidney fibrosis

C Ding, B Wang, XF Lai, Y Guo, G Tesch, X Ding… - Materials Today Bio, 2023 - Elsevier
Renal fibrosis is a pathological feature of chronic kidney disease and its progression
correlates with kidney function impairment. Since there are currently no specific therapies for …

Relaxin reverses inflammatory and immune signals in aged hearts

B Martin, BA Gabris-Weber, R Reddy, G Romero… - PloS one, 2018 - journals.plos.org
Background 'Healthy'aging drives structural and functional changes in the heart including
maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for …

Acute blood pressure elevation: Therapeutic approach

M Salvetti, A Paini, F Bertacchini, D Stassaldi… - Pharmacological …, 2018 - Elsevier
International guidelines have suggested to avoid the term “hypertensive crisis” for the
description of an acute and severe increase in blood pressure (BP) and to consider the …

Current pharmacological therapies in heart failure patients

ML Muiesan, A Paini, C Agabiti Rosei… - High Blood Pressure & …, 2017 - Springer
Heart failure (HF) is a major problem of public health. More than 23 million patients
worldwide are affected by heart failure. Despite incidence and prevalence of heart failure …