Complex chromosome rearrangements, known as chromoanagenesis, are widespread in
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …

Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …

Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to
cancer pathogenesis that is identified in most cancer types and is associated with poor …

Genetic material is organized in the form of chromosomes, which need to be segregated
accurately into two daughter cells in each cell cycle. However, chromosome fusion or the …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

A cell dealing with a broken chromosome in mitosis is like a driver dealing with a flat tire on
the highway: damage repair must occur under non-ideal circumstances. Mitotic chromosome …

Human cancers share requirements for phosphorylation-dependent signaling, mitotic
hyperactivity, and survival after DNA damage. The oncoprotein CIP2A (cancerous inhibitor …

Errors in mitosis can generate micronuclei that entrap mis-segregated chromosomes, which
are susceptible to catastrophic fragmentation through a process termed chromothripsis. The …

Simple Summary The evolutionary events, carcinogenesis and speciation, are presumably
based on a phase of 'genome instability'caused by DNA breakage and mis-repair leading to …