Synthesis of thiazolidinone based on quinolone moiety was established starting from 4-
hydroxyquinol-2-ones. The strategy started with the reaction of ethyl bromoacetate with 4 …

Research has placed a great deal of emphasis on molecule development and discovery
with substantial biological profiling in recent years. Despite the significant side effects …

A simple green method has been developed for the synthesis of a series of new 3-phenyl-6-
(substituted)-thiopyrano [2, 3-d] thiazole-2, 5, 7 (6H)-triones, 6-cyano-2-oxo-3-phenyl …

Objective To synthesize and initial pharmacological assessment of new analogues of
nabumetone by studying their interactions with COX-1 and COX-2 by docking and to …

In the present study, a series of new pyrazoline derivatives bearing sulfanilamido moiety
were synthesized and obtained in good yields. The chemical structures of the compounds …

Four different well-known non-steroidal anti-inflammatory drugs (naproxen, ketoprofen,
diclofenac and ibuprofen) were linked to gatifloxacin anti-infective drug which possess anti …

New compounds of trimethoprim heterocyclic derivatives were synthesized. These
compounds were synthesized through the condensation reaction between trimethoprim with …

Objective: The aim of this study is to produce novel 4 (3 H)-quinazolinone derivatives,
analyze their efficacy as antibacterial and antifungal agents, and investigate their antioxidant …

To develop novel anti-inflammatory scaffolds, a new series of 4, 5-dihydro-1H-pyrazole-1-yl
acetate derivatives synthesized through different chemical reactions and validated …

In last decade, many researchers have been developed potent heterocyclic compounds.
Pyrazolines are significant pharmacophore due to its medicinal applications such as …