Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

Background Recent changes in nutrition and lifestyle have provoked an unprecedented
increase in the prevalence of obesity and metabolic disorders. Recognition of the adverse …

This review addresses the possible role of the insulin‐like growth factor (IGF)‐axis in normal
glucose homoeostasis and in the etiopathogenesis of type 2 diabetes. IGF‐I, a peptide …

Background Insulin and insulin-like growth factors (IGFs) signal through a highly conserved
pathway and control growth and metabolism in both vertebrates and invertebrates. In …

The changes in the brain signaling systems play an important role in etiology and
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …

Type 2 diabetes (T2D) is a leading cause of death and disability worldwide. It is a chronic
metabolic disorder that develops due to an interplay of genetic, lifestyle, and environmental …

Context Growth hormone (GH) and IGF-1 help regulate hepatic glucose and lipid
metabolism, and reductions in these hormones may contribute to development of …

The insulinlike growth factor-I (IGF-I) is an important factor which regulates a variety of
cellular responses in multiple biological systems. The IGF1 gene comprises a highly …

Type 2 diabetes mellitus (T2DM), a chronic disease increasing rapidly worldwide, is well
established as an important risk factor for various types of cancer. Although many factors …

Diabetic cardiomyopathy (DCM) is commonly defined as cardiomyopathy in patients with
diabetes mellitus in the absence of coronary artery disease and hypertension. As DCM is …