One of the most salient features of Bacillus subtilis and related bacilli is their natural capacity
to secrete a variety of proteins into their environment, frequently to high concentrations. This …

Bacterial sigma (σ) factors are an essential component of RNA polymerase and determine
promoter selectivity. The substitution of one σ factor for another can redirect some or all of …

Secretory proteins perform a variety of important “remote-control” functions for bacterial
survival in the environment. The availability of complete genome sequences has allowed us …

In 1971, Gunter Blobel and David Sabatini published the first report of the signal hypothesis
where they propose that proteins contain information within their amino acid sequences for …

The gram-positive bacterium Staphylococcus aureus is a frequent component of the human
microbial flora that can turn into a dangerous pathogen. As such, this organism is capable of …

In contrast to Gram-negative bacteria, secretory proteins of Gram-positive bacteria only need
to traverse a single membrane to enter the extracellular environment. For this reason, Gram …

Bacillus subtilis has become a widely used microbial cell factory for the production of
recombinant proteins, especially those associated with foods and food processing. Recent …

Bacillus subtilis produces many antibiotics of varying structures and specificity. Here we
identify a prominent role for σW, an extracytoplasmic function (ECF) sigma factor, in …

Bacillus species are widely recognized as good industrial platform strains, which can
produce a variety of valuable products including enzymes and functional proteins. Bacillus …

The Bacillus subtilis extracytoplasmic function (ECF) σ factor σW controls a large regulon
that is strongly induced by alkali shock. To define the physiological role of σW we have …