Proteases and protease inhibitors in infectious diseases
There are numerous proteases of pathogenic organisms that are currently targeted for
therapeutic intervention along with many that are seen as potential drug targets. This review …
therapeutic intervention along with many that are seen as potential drug targets. This review …
Bacterial and fungal proteolytic enzymes: production, catalysis and potential applications
RR Da Silva - Applied Biochemistry and Biotechnology, 2017 - Springer
Submerged and solid-state bioprocesses have been extensively explored worldwide and
employed in a number of important studies dealing with microbial cultivation for the …
employed in a number of important studies dealing with microbial cultivation for the …
Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease
K Vu, R Tham, JP Uhrig, GR Thompson III… - MBio, 2014 - Am Soc Microbiol
Cryptococcus spp. cause life-threatening fungal infection of the central nervous system
(CNS), predominantly in patients with a compromised immune system. Why Cryptococcus …
(CNS), predominantly in patients with a compromised immune system. Why Cryptococcus …
[HTML][HTML] Bioinformatics based discovery of new keratinases in protease family M36
Keratinases are proteases that can catalyze the degradation of insoluble keratinous
biomass. Keratinases in protease family M36 (MEROPS database) are endo-acting …
biomass. Keratinases in protease family M36 (MEROPS database) are endo-acting …
Target-and prodrug-based design for fungal diseases and cancer-associated fungal infections
N Liu, J Tu, Y Huang, W Yang, Q Wang, Z Li… - Advanced Drug Delivery …, 2023 - Elsevier
Invasive fungal infections (IFIs) are emerging as a serious threat to public health and are
associated with high incidence and mortality. IFIs also represent a frequent complication in …
associated with high incidence and mortality. IFIs also represent a frequent complication in …
[HTML][HTML] Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
Akkermansia muciniphila, a mucin-degrading microbe found in the human gut, is often
associated with positive health outcomes. The abundance of A. muciniphila is modulated by …
associated with positive health outcomes. The abundance of A. muciniphila is modulated by …
[HTML][HTML] Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins
Innate immunity in animals including humans encompasses the complement system, which
is considered an important host defense mechanism against Aspergillus fumigatus, one of …
is considered an important host defense mechanism against Aspergillus fumigatus, one of …
[HTML][HTML] Bioinformatic mapping of a more precise Aspergillus niger degradome
Z Dong, S Yang, BH Lee - Scientific reports, 2021 - nature.com
Aspergillus niger has the ability to produce a large variety of proteases, which are of
particular importance for protein digestion, intracellular protein turnover, cell signaling …
particular importance for protein digestion, intracellular protein turnover, cell signaling …
Transcriptome of an entomophthoralean fungus (Pandora formicae) shows molecular machinery adjusted for successful host exploitation and transmission
Pandora formicae is an obligate entomopathogenic fungus from the phylum
Entomophthoromycota, known to infect only ants from the genus Formica. In the final stages …
Entomophthoromycota, known to infect only ants from the genus Formica. In the final stages …
[HTML][HTML] The metalloprotease, Mpr1, engages AnnexinA2 to promote the transcytosis of fungal cells across the blood-brain barrier
Eukaryotic pathogens display multiple mechanisms for breaching the blood-brain barrier
(BBB) and invading the central nervous system (CNS). Of the fungal spp., that cause disease …
(BBB) and invading the central nervous system (CNS). Of the fungal spp., that cause disease …