Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic
kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to
overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient …

Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily
of endocrine FGFs with evolutionarily conserved functions in worms and fruit flies. FAM20C …

Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases
expressed on the cell membrane that play crucial roles in both developmental and adult …

Abstract Fibroblast growth factor 23 (FGF23) was initially characterized as an important
regulator of phosphate and calcium homeostasis. New research advances demonstrate that …

Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a …