While gait variability may reflect subtle changes due to aging or cognitive impairment (CI),
associated brain characteristics remain unclear. We summarize structural and functional …

Parkinson's disease (PD) is the second commonest neurodegenerative disorder in the world
with a rising prevalence. The pathophysiology is multifactorial but aggregation of misfolded …

Gait is complex, described by diverse characteristics underpinned by widespread central
nervous system networks including motor and cognitive functions. Despite this, neural …

ABSTRACT PD, PD with dementia, and dementia with Lewy bodies are clinical syndromes
characterized by the neuropathological accumulation of alpha‐synuclein in the CNS that …

Objective To examine the associations of physical activity, Alzheimer disease (AD), and
other brain pathologies and cognition in older adults. Methods We studied 454 brain …

Introduction Nonhuman primates may serve as excellent models of sporadic age-associated
brain β-amyloid deposition and Alzheimer's disease pathologic changes. We examined …

Background: Gait disturbance is an early, cardinal feature of Parkinson's disease (PD)
associated with falls and reduced physical activity. Progression of gait impairment in …

Background: Gait impairments are emerging predictors of dementia. However, few studies
have examined whether gait predicts decline in specific cognitive domains. Objective: This …

Background: Approximately 30% of older adults have disrupted gait. It is associated with
increased risk of cognitive decline, disability, dementia, and death. Additionally, most older …

Background Daily physical activity patterns differ by Alzheimer's disease (AD) status and
might signal cognitive risk. It is critical to understand whether patterns are disrupted early in …