Aerobic exercise in the management of metabolic dysfunction associated fatty liver disease

MV Machado - Diabetes, Metabolic Syndrome and Obesity, 2021 - Taylor & Francis
Sedentarism is the pandemic of modern times. It is associated with several medical
conditions including obesity, type 2 diabetes mellitus, cardiovascular diseases and also liver …

Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease

J Wang, W He, PJ Tsai, PH Chen, M Ye, J Guo… - Lipids in Health and …, 2020 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic syndrome. Imbalances
between liver lipid output and input are the direct causes of NAFLD, and hepatic steatosis is …

Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-α signaling in obese mice

TA Diniz, EA de Lima Junior, AA Teixeira, LA Biondo… - Life sciences, 2021 - Elsevier
Liver steatosis is one of the main drivers for the development of whole-body insulin
resistance. Conversely, aerobic training (AT) has been suggested as non-pharmacological …

Moderate aerobic exercise training prevents the augmented hepatic glucocorticoid response induced by high-fat diet in mice

J Dassonvalle, F Díaz-Castro… - International journal of …, 2020 - mdpi.com
Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is
associated with the development of obesity and metabolic syndrome. However, it is not …

[HTML][HTML] Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD

H Li, Y Dun, W Zhang, B You, Y Liu, S Fu, L Qiu… - Life sciences, 2021 - Elsevier
Aim To emphasize the mechanism of the effect of exercise on lipid droplet (LD) metabolism
disorder in nonalcoholic fatty liver disease (NAFLD). Main methods C57BL/6J mice were …

Moderate treadmill exercise alleviates NAFLD by regulating the biogenesis and autophagy of lipid droplet

Y Yang, X Li, Z Liu, X Ruan, H Wang, Q Zhang, L Cao… - Nutrients, 2022 - mdpi.com
Lipid droplet is a dynamic organelle that undergoes periods of biogenesis and degradation
under environmental stimuli. The excessive accumulation of lipid droplets is the major …

Excess accumulation of lipid impairs insulin sensitivity in skeletal muscle

SS Park, YK Seo - International Journal of Molecular Sciences, 2020 - mdpi.com
Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a
living organism. Compelling evidence supports a role for excess fatty acids synthesized in …

Exercise and Metformin Intervention Prevents Lipotoxicity‐Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO‐1 …

Y Zhang, Y Liu, X Liu, X Yuan, M Xiang… - Oxidative Medicine …, 2022 - Wiley Online Library
Objective. Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly
coexist and act synergistically to drive adverse clinical outcomes. This study is aimed at …

Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD

JC Bórquez, F Díaz-Castro, F Pino-de La Fuente… - Metabolism, 2024 - Elsevier
Background and aim The excessive accumulation of lipid droplets (LDs) is a defining
characteristic of nonalcoholic fatty liver disease (NAFLD). The interaction between LDs and …

Exercise regulation of hepatic lipid droplet metabolism

F Pino-de la Fuente, JC Bórquez, F Díaz-Castro… - Life Sciences, 2022 - Elsevier
Lipid droplets (LD) are not just lipid stores. They are now recognized as highly dynamic
organelles, having a life cycle that includes biogenesis, growth, steady-state, transport, and …