The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …

Abstract During inflammation, Ly6Chi monocytes are rapidly mobilized from the bone
marrow (BM) and are recruited into inflamed tissues, where they undergo monocyte-to …

Phagocytes form a family of immune cells that play a crucial role in tissue maintenance and
help orchestrate the immune response. This family of cells can be separated by their nuclear …

As the resident macrophages of the brain and spinal cord, microglia are crucial for the
phagocytosis of infectious agents, apoptotic cells and synapses. During brain injury or …

Multiple sclerosis is a chronic inflammatory disease of the central nervous system.
Astrocytes are heterogeneous glial cells that are resident in the central nervous system and …