Scopolamine is used as a standard/reference drug for inducing cognitive deficits in healthy
humans and animals. Effects are often interpreted in terms of a role of acetylcholine in …

Perceptual inference refers to the ability to infer sensory stimuli from predictions that result
from internal neural representations built through prior experience. Methods of Bayesian …

Rationale The nonselective muscarinic antagonist scopolamine hydrobromide (SCOP) is
employed as the gold standard for inducing memory impairments in healthy humans and …

Scopolamine has been used as a pharmacologic model for cognitive impairments in
dementia and Alzheimer's disease. The validity of this model seems to be limited because …

Women have an increased risk of developing Alzheimer's Dementia (AD) compared to men.
It has been postulated that this risk may be modulated by a reduction in the neuroprotective …

The Göttingen minipig is fast becoming the standard for assessing dermal chemical hazards
because, like most swine, its skin is predictive of human skin response and because this …

Organophosphorus compounds (OP) pose a significant threat. Administration of human
butyrylcholinesterase (HuBChE) may reduce or prevent OP toxicity. Thus, we evaluated the …

The effects of a large dose of human serum butyrylcholinesterase (HuBChE) were evaluated
in rhesus monkeys using a serial-probe recognition (SPR) task designed to assess attention …

Information concerning the major neurotransmitters critical for auditory memory is sparse.
One possibility is the cholinergic system, important for performance in some tasks requiring …

Acetylcholine (ACh) is a neurotransmitter acting via muscarinic and nicotinic receptors that is
implicated in several cognitive functions and impairments, such as Alzheimer's disease. It is …