Nanotechnology has provided great opportunities for managing neoplastic conditions at
various levels, from preventive and diagnostic to therapeutic fields. However, when it comes …

Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …

Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …

INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

The tumour microenvironment plays an essential role in malignancy, and neurons have
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …

Brain, the major organ of the central nervous system controls and processes most of body
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …

To what extent does the subarachnoid cerebrospinal fluid (CSF) compartment communicate
directly with the extravascular compartment of human brain tissue? Interconnection between …

Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has
demonstrated the importance of tumour cell migration through confining tracks in vivo. These …

Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16
months. Recent research has revealed novel insights into the outstanding heterogeneity of …

Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized by
diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend …