Nanobodies: natural single-domain antibodies
S Muyldermans - Annual review of biochemistry, 2013 - annualreviews.org
Sera of camelids contain both conventional heterotetrameric antibodies and unique
functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric …
functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric …
Nanobodies®: new ammunition to battle viruses
P Vanlandschoot, C Stortelers, E Beirnaert, LI Ibañez… - Antiviral research, 2011 - Elsevier
In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also
in all other species of the Camelidae family. These antibodies do not contain a light chain …
in all other species of the Camelidae family. These antibodies do not contain a light chain …
Ultra-sensitive serial profiling of SARS-CoV-2 antigens and antibodies in plasma to understand disease progression in COVID-19 patients with severe disease
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected
over 21 million people worldwide since August 16, 2020. Compared to PCR and serology …
over 21 million people worldwide since August 16, 2020. Compared to PCR and serology …
Coming together at the hinges: Therapeutic prospects of IgG3
TH Chu, EF Patz Jr, ME Ackerman - MAbs, 2021 - Taylor & Francis
The human IgG3 subclass is conspicuously absent among the formats for approved
monoclonal antibody therapies and Fc fusion protein biologics. Concern about the potential …
monoclonal antibody therapies and Fc fusion protein biologics. Concern about the potential …
Alternative reagents to antibodies in imaging applications
R Bedford, C Tiede, R Hughes, A Curd… - Biophysical …, 2017 - Springer
Antibodies have been indispensable tools in molecular biology, biochemistry and medical
research. However, a number of issues surrounding validation, specificity and batch …
research. However, a number of issues surrounding validation, specificity and batch …
[HTML][HTML] Single-domain antibody fragments derived from heavy-chain antibodies: a review
L Eyer, K Hruska - Veterinarni Medicina, 2012 - vetmed.agriculturejournals.cz
Single-domain antibody (sdAb) fragments derived from heavy-chain antibodies of camelids
and cartilaginous fish represent a new generation of therapeutic agents and …
and cartilaginous fish represent a new generation of therapeutic agents and …
Peste des petits ruminants infection in domestic ruminants in Sudan
KS Intisar, YH Ali, MA Haj, MAT Sahar… - Tropical animal health …, 2017 - Springer
The existence of peste des petits ruminants (PPR) in domestic ruminants and camels in
Sudan during 2008–2012 was investigated. Lung tissues and serum samples were …
Sudan during 2008–2012 was investigated. Lung tissues and serum samples were …
[HTML][HTML] Efficacy of a Haemonchus contortus vaccine under field conditions in young alpacas
Anthelmintic resistance to Haemonchus contortus creates increasing management
challenges with small ruminants and camelids. The commercial vaccine, Barbervax® …
challenges with small ruminants and camelids. The commercial vaccine, Barbervax® …
Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing
N Miyazaki, N Kiyose, Y Akazawa… - The journal of …, 2015 - academic.oup.com
The antigen-binding domain of camelid dimeric heavy chain antibodies, known as VHH or
Nanobody, has much potential in pharmaceutical and industrial applications. To establish …
Nanobody, has much potential in pharmaceutical and industrial applications. To establish …
Polyclonal alpaca antibodies protect against hantavirus pulmonary syndrome in a lethal Syrian hamster model
P Sroga, A Sloan, BM Warner, K Tierney, J Lew… - Scientific Reports, 2021 - nature.com
The use of antibody-based therapies for the treatment of high consequence viral pathogens
has gained interest over the last fifteen years. Here, we sought to evaluate the use of unique …
has gained interest over the last fifteen years. Here, we sought to evaluate the use of unique …