Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
The biology of CRISPR-Cas: backward and forward
F Hille, H Richter, SP Wong, M Bratovič, S Ressel… - Cell, 2018 - cell.com
In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
Updates on the pathogenicity status of Pseudomonas aeruginosa
Highlights•MDR P. aeruginosa is one of the major causes of the nosocomial
infections.•Virulence factors involved in pathogenicity were described.•Potential inhibitors of …
infections.•Virulence factors involved in pathogenicity were described.•Potential inhibitors of …
Alternative functions of CRISPR–Cas systems in the evolutionary arms race
CRISPR–Cas systems of bacteria and archaea comprise chromosomal loci with typical
repetitive clusters and associated genes encoding a range of Cas proteins. Adaptation of …
repetitive clusters and associated genes encoding a range of Cas proteins. Adaptation of …
The discovery, mechanisms, and evolutionary impact of anti-CRISPRs
AL Borges, AR Davidson… - Annual review of …, 2017 - annualreviews.org
Bacteria and archaea use CRISPR-Cas adaptive immune systems to defend themselves
from infection by bacteriophages (phages). These RNA-guided nucleases are powerful …
from infection by bacteriophages (phages). These RNA-guided nucleases are powerful …
The CRISPR-Cas mechanism for adaptive immunity and alternate bacterial functions fuels diverse biotechnologies
S Newsom, HP Parameshwaran, L Martin… - Frontiers in cellular and …, 2021 - frontiersin.org
Bacterial and archaeal CRISPR-Cas systems offer adaptive immune protection against
foreign mobile genetic elements (MGEs). This function is regulated by sequence specific …
foreign mobile genetic elements (MGEs). This function is regulated by sequence specific …
Both toxic and beneficial effects of pyocyanin contribute to the lifecycle of Pseudomonas aeruginosa
LA Meirelles, DK Newman - Molecular microbiology, 2018 - Wiley Online Library
Pseudomonas aeruginosa, an opportunistic pathogen, produces redox‐active pigments
called phenazines. Pyocyanin (PYO, the blue phenazine) plays an important role during …
called phenazines. Pyocyanin (PYO, the blue phenazine) plays an important role during …
Targeting of temperate phages drives loss of type I CRISPR–Cas systems
C Rollie, A Chevallereau, BNJ Watson, T Chyou… - Nature, 2020 - nature.com
On infection of their host, temperate viruses that infect bacteria (bacteriophages; hereafter
referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of …
referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of …
Cargo Genes of Tn7-Like Transposons Comprise an Enormous Diversity of Defense Systems, Mobile Genetic Elements, and Antibiotic Resistance Genes
Transposition is a major mechanism of horizontal gene mobility in prokaryotes. However,
exploration of the genes mobilized by transposons (cargo) is hampered by the difficulty in …
exploration of the genes mobilized by transposons (cargo) is hampered by the difficulty in …
Evolution and ecology of CRISPR
ER Westra, AJ Dowling, JM Broniewski… - Annual Review of …, 2016 - annualreviews.org
CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-
associated) systems are prokaryotic adaptive immune systems that provide protection …
associated) systems are prokaryotic adaptive immune systems that provide protection …