Recently, phage display technology has been announced as the recipient of Nobel Prize in
Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be …

Antiestrogen therapy remains one of the most widely used and effective treatments for the
management of endocrine responsive breast cancers. This reflects the ability of …

Estrogen receptors (ERs) mediate most of the biological effects of estrogen in mammary and
uterine epithelial cells by binding to estrogen response elements in the promoter region of …

OBJECTIVE: To update the 1997 clinical practice guidelines for the use of tumor marker
tests in the prevention, screening, treatment, and surveillance of breast and colorectal …

Disruption of apoptosis may allow metastatic cell survival and confer resistance to
chemotherapeutic drugs. We have analysed the molecular pathways that activate these …

There is a balance between cell death and survival in living organisms. The ability of cells to
sense their environment and decide to survive or die is dependent largely upon growth …

Therapies that target the synthesis of estrogen or the function of estrogen receptor (s) have
been developed to treat breast cancer. While these approaches have proven to be …

We investigated the effect of a chronic exposure to high levels of free fatty acid (FFA; 2
mmol/L oleate/palmitate 2: 1) or glucose (16.7 mmol/L) on islet cell apoptosis. Apoptosis was …

Human epidermal growth factor receptor 2 (HER2) expression in breast cancer is associated
with an aggressive phenotype and poor prognosis, making it an appealing therapeutic …

The transcription factor nuclear factor-κB (NF-κB) regulates genes important for tumor
invasion, metastasis and chemoresistance. Normally, NF-κB remains sequestered in an …