The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …

Tacrolimus (Tac) is widely used for the prevention of rejection after solid organ
transplantation. Finding the optimal balance between effective Tac concentrations and …

Tacrolimus is a pivotal immunosuppressant agent used in solid-organ transplantation. It was
originally formulated for oral administration as Prograf®, a twice-daily immediate-release …

Background This study investigated pharmacokinetic and pharmacogenetic differences
between a modified-release once-daily formulation of tacrolimus (Tac-QD) and the original …

Metrics are discussed which are used for the evaluation of bioequivalence of modified-
release formulations. In order to ensure the therapeutic equivalence of the compared drug …

Poor adherence to immunosuppressive medications may be the most important barrier to
long term graft survival. An understanding of medication adherence and its determinants is …

While CYP3A5 polymorphisms are used to predict the initial dosage of tacrolimus therapy,
the predictive capability of genetic information for dosing at early stage post-renal …

The science of drug delivery has evolved considerably and has led to the development of
multiple sustained release formulations. Each of these formulations can present particular …

Purpose The pharmacokinetics of orally administered immediate-release, twice-daily (BID)
and modified-release, once-daily (QD) formulations of tacrolimus have high interindividual …

Background The aim of this study was to compare the within-patient variability trough levels
(C o), dose-adjusted C o, and dose requirements of Prograf and Advograf with CYP3A5 …