Generating reactive oxygen species (ROS) is necessary for both physiology and pathology.
An imbalance between endogenous oxidants and antioxidants causes oxidative stress …

Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have
a high specific metabolic rate, play an essential role in the long-term regulation of arterial …

Essential hypertension (EH) is a complex, polygenic condition with no single causative
agent. Despite advances in our understanding of the pathophysiology of EH, hypertension …

Renal disease affects millions of people worldwide, imposing an enormous financial burden
for health-care systems. Recent evidence suggests that mitochondria play an important role …

The physiological evidence linking the production of superoxide, hydrogen peroxide, and
nitric oxide in the renal medullary thick ascending limb of Henle (mTAL) to regulation of …

This study reports the consequences of knocking out NADPH (nicotinamide adenine
dinucleotide phosphate) oxidase 4 (Nox4) on the development of hypertension and kidney …

Hypertension remains an important modifiable risk factor for cardiovascular disease,
associated with increased morbidity and mortality. Deciphering the mechanisms involved in …

Fumarase catalyzes the interconversion of fumarate and L-malate in the tricarboxylic acid
cycle. The Dahl salt-sensitive (SS) rat, a model of salt-sensitive hypertension, exhibits …

Mitochondrial injury contributes to renal dysfunction in several models of renal disease, but
its involvement in human hypertension remains unknown. Fragments of the mitochondrial …

Experimentally renal tissue hypoxia appears to play an important role in the pathogenesis of
chronic kidney disease (CKD) and arterial hypertension (AHT). In this study we measured …