Homocysteine, B vitamins, and cognitive impairment

AD Smith, H Refsum - Annual review of nutrition, 2016 - annualreviews.org
Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Vitamin B12 in Health and Disease

F O'Leary, S Samman - Nutrients, 2010 - mdpi.com
Vitamin B12 is essential for DNA synthesis and for cellular energy production. This review
aims to outline the metabolism of vitamin B12, and to evaluate the causes and …

Vitamin B12

AD Smith, MJ Warren, H Refsum - Advances in food and nutrition research, 2018 - Elsevier
The biosynthesis of B 12, involving up to 30 different enzyme-mediated steps, only occurs in
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …

Cognitive impairment and vitamin B12: a review

E Moore, A Mander, D Ames, R Carne… - International …, 2012 - cambridge.org
Background: This review examines the associations between low vitamin B12 levels,
neurodegenerative disease, and cognitive impairment. The potential impact of comorbidities …

[HTML][HTML] Mild cognitive impairment and dementia: the importance of modifiable risk factors

T Etgen, D Sander, H Bickel, H Förstl - Deutsches Ärzteblatt …, 2011 - ncbi.nlm.nih.gov
Background Mild cognitive impairment (MCI), a common condition among the elderly, is
defined as a deterioration of memory, attention, and cognitive function that exceeds what …

Efficacy of cognitive rehabilitation therapies for mild cognitive impairment (MCI) in older adults: working toward a theoretical model and evidence-based interventions

M Huckans, L Hutson, E Twamley, A Jak, J Kaye… - Neuropsychology …, 2013 - Springer
To evaluate the efficacy of cognitive rehabilitation therapies (CRTs) for mild cognitive
impairment (MCI). Our review revealed a need for evidence-based treatments for MCI and a …

Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial.

JM Armitage, L Bowman, RJ Clarke, K Wallendszus… - Jama, 2010 - europepmc.org
Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and
major morbidity in myocardial infarction survivors: a randomized trial. - Abstract - Europe PMC …

Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points

SN Fedosov, A Brito, JW Miller, R Green… - Clinical Chemistry and …, 2015 - degruyter.com
Background: A novel approach to determine vitamin B12 status is to combine four blood
markers: total B12 (B12), holotranscobalamin (holoTC), methylmalonic acid (MMA) and total …

Vitamin B12 status and rate of brain volume loss in community-dwelling elderly

A Vogiatzoglou, H Refsum, C Johnston, SM Smith… - Neurology, 2008 - AAN Enterprises
Objectives: To investigate the relationship between markers of vitamin B12 status and brain
volume loss per year over a 5-year period in an elderly population. Methods: A prospective …

[图书][B] Folate in health and disease

LB Bailey - 2009 - taylorfrancis.com
During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …