Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers
countermeasures aimed to restore cardiac output. These responses are compensatory at …

Heart failure (HF) is a complex clinical syndrome characterized by the activation of at least
several neurohumoral pathways that have a common role in maintaining cardiac output and …

The human genome encodes nine different adrenoceptor genes. These are grouped into
three families, namely, the α 1-, α 2-, and β-adrenoceptors, with three family members each …

Abstract β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors
known as G protein–coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for …

As a commonly used antibacterial agent in daily consumer products, triclosan (TCS) has
attracted significant attention due to its potential environmental risks. In this study, we …

G‐protein‐coupled receptors (GPCRs) are the targets for many drugs, and genetic variation
in coding and noncoding regions is apparent in many such receptors. In this superfamily …

Objectives: This study sought to identify genetic modifiers of β-blocker response and long-
term survival in heart failure (HF). Background: Differences in β-blocker treatment effect …

In the 15 years following the release of the first complete human genome sequences, our
understanding of rare and common genetic variation as determinants of cardiovascular …

Patients vary in their responses to drug therapy, and some of that variability is genetically
determined. This review outlines general approaches used to identify genetic variation that …