Past, present, and future of allergen immunotherapy vaccines

Y Dorofeeva, I Shilovskiy, I Tulaeva, M Focke‐Tejkl… - Allergy, 2021 - Wiley Online Library
Allergen‐specific immunotherapy (AIT) is an allergen‐specific form of treatment for patients
suffering from immunoglobulin E (IgE)‐associated allergy; the most common and important …

Advanced technologies for the preservation of mammalian biospecimens

H Huang, X He, ML Yarmush - Nature biomedical engineering, 2021 - nature.com
The three classical core technologies for the preservation of live mammalian biospecimens—
slow freezing, vitrification and hypothermic storage—limit the biomedical applications of …

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

B Sawitzki, PN Harden, P Reinke, A Moreau… - The Lancet, 2020 - thelancet.com
Background Use of cell-based medicinal products (CBMPs) represents a state-of-the-art
approach for reducing general immunosuppression in organ transplantation. We tested …

[HTML][HTML] Analyses of the short-and long-term graft survival after kidney transplantation in Europe between 1986 and 2015

M Coemans, C Süsal, B Döhler, D Anglicheau… - Kidney international, 2018 - Elsevier
The evolution of kidney allograft survival remains insufficiently studied in the context of the
changing donor and recipient demographics. Since European data are lacking we …

A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection

MM Kaminski, MA Alcantar, IT Lape… - Nature biomedical …, 2020 - nature.com
In organ transplantation, infection and rejection are major causes of graft loss. They are
linked by the net state of immunosuppression. To diagnose and treat these conditions …

Contribution of non-HLA incompatibility between donor and recipient to kidney allograft survival: genome-wide analysis in a prospective cohort

R Reindl-Schwaighofer, A Heinzel, A Kainz… - The Lancet, 2019 - thelancet.com
Background The introduction of HLA matching of donors and recipients was a breakthrough
in kidney transplantation. However, half of all transplanted kidneys still fail within 15 years …

[HTML][HTML] Single-cell analysis reveals immune landscape in kidneys of patients with chronic transplant rejection

Y Liu, J Hu, D Liu, S Zhou, J Liao, G Liao, S Yang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Single-cell RNA sequencing (scRNA-seq) has provided an unbiased assessment
of specific profiling of cell populations at the single-cell level. Conventional renal biopsy and …

Mesenchymal stem cells and extracellular vesicles in therapy against kidney diseases

Y Huang, L Yang - Stem cell research & therapy, 2021 - Springer
Kidney diseases pose a threat to human health due to their rising incidence and fatality rate.
In preclinical and clinical studies, it has been acknowledged that mesenchymal stem cells …

[HTML][HTML] Renal normothermic machine perfusion: the road toward clinical implementation of a promising pretransplant organ assessment tool

TL Hamelink, B Ogurlu, J De Beule, VA Lantinga… - …, 2022 - journals.lww.com
The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

Development and validation of a peripheral blood mRNA assay for the assessment of antibody-mediated kidney allograft rejection: a multicentre, prospective study

E Van Loon, S Gazut, S Yazdani, E Lerut, H de Loor… - …, 2019 - thelancet.com
Background Antibody-mediated rejection, a leading cause of renal allograft graft failure, is
diagnosed by histological assessment of invasive allograft biopsies. Accurate non-invasive …