The role of BMP signaling in osteoclast regulation

B Heubel, A Nohe - Journal of developmental biology, 2021 - mdpi.com
The osteogenic effects of Bone Morphogenetic Proteins (BMPs) were delineated in 1965
when Urist et al. showed that BMPs could induce ectopic bone formation. In subsequent …

Role of exosomal MicroRNAs and their crosstalk with oxidative stress in the pathogenesis of osteoporosis

J Lu, Y Zhang, J Liang, J Diao, P Liu… - Oxidative medicine and …, 2021 - Wiley Online Library
Osteoporosis (OP) is an aging‐related disease involving permanent bone tissue atrophy.
Most patients with OP show high levels of oxidative stress (OS), which destroys the …

[HTML][HTML] Psoralen and bakuchiol ameliorate M-CSF plus RANKL-induced osteoclast differentiation and bone resorption via inhibition of AKT and AP-1 pathways in …

L Chai, K Zhou, S Wang, H Zhang, N Fan, J Li… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Psoralen and bakuchiol are the main active compounds found in the
traditional Chinese medicine Psoralea corylifolia L., and have been used to treat …

Triptolide prevents bone loss via suppressing osteoclastogenesis through inhibiting PI3K‐AKT‐NFATc1 pathway

J Cui, X Li, S Wang, Y Su, X Chen… - Journal of Cellular …, 2020 - Wiley Online Library
Bone loss (osteopenia) is a common complication in human solid tumour. In addition, after
surgical treatment of gynaecological tumour, osteoporosis often occurs due to the …

Urolithin B suppresses osteoclastogenesis via inhibiting RANKL‐induced signalling pathways and attenuating ROS activities

Z Qu, H An, M Feng, W Huang, D Wang… - Journal of Cellular …, 2022 - Wiley Online Library
Osteoporosis (OP) has severely affected human health, which is characterized by abnormal
differentiation of osteoclasts. Urolithin B (UB), as a potential natural drug, has been reported …

[HTML][HTML] LncRNA-AK131850 sponges MiR-93-5p in newborn and mature osteoclasts to enhance the secretion of vascular endothelial growth factor a promoting …

H Quan, M Liang, N Li, C Dou, C Liu, Y Bai… - Cellular physiology and …, 2018 - karger.com
Background/Aims: In the process of bone development and remodeling, the vasculature is
regarded as the communicative network between the bone and neighboring tissues …

Advances in the study of traditional Chinese medicine affecting bone metabolism through modulation of oxidative stress

J Li, H Cao, X Zhou, J Guo, C Zheng - Frontiers in Pharmacology, 2023 - frontiersin.org
Bone metabolic homeostasis is dependent on coupled bone formation dominated by
osteoblasts and bone resorption dominated by osteoclasts, which is a process of dynamic …

Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides' Stem via UHPLC-Orbitrap-Ion Trap Mass …

H Hu, C Hu, J Peng, AK Ghosh, A Khan… - Frontiers in …, 2021 - frontiersin.org
The stem of Picrasma quassioides (PQ) was recorded as a prominent traditional Chinese
medicine, Kumu, which was effective for microbial infection, inflammation, fever, and …

Genus Picrasma: A comprehensive review on its ethnopharmacology, phytochemistry and bioactivities

WH Xu, ZS Liang, XM Su, RX He, Q Liang - Journal of Ethnopharmacology, 2021 - Elsevier
Abstract Ethnopharmacological relevance The genus Picrasma belongs to the
Simaroubaceae family and contains six species which are mainly distributed in tropical and …

Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews

MDH Mohd Jamil, M Taher, D Susanti, MA Rahman… - Nutrients, 2020 - mdpi.com
Picrasma quassioides is a member of the Simaroubaceae family commonly grown in the
regions of Asia, the Himalayas, and India and has been used as a traditional herbal …