Fibroblast growth factors (fgfs) are widely believed to activate their receptors by mediating
receptor dimerization. Here we show, however, that the FGF receptors form dimers in the …

Our understanding of complex living systems is limited by our capacity to perform
experiments in high throughput. While robotic systems have automated many traditional …

The guts of neonatal mammals and stomachless fish have a limited capacity for luminal
protein digestion, which allows oral acquisition of antibodies and antigens. However, how …

VEGFR-2 is the primary regulator of angiogenesis, the development of new blood vessels
from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of …

Increased intercellular tension is associated with enhanced cell proliferation and tissue
growth. Here, we present evidence for a force-transduction mechanism that links mechanical …

Changing nutritional conditions challenge microbes and shape their evolutionary
optimization. Here, we used real-time metabolomics to investigate the role of glycogen in the …

Here we introduce the fully quantified spectral imaging (FSI) method as a new tool to probe
the stoichiometry and stability of protein complexes in biological membranes. The FSI …

Förster resonance energy transfer (FRET) experiments are often used to study interactions
between integral membrane proteins in cellular membranes. However, in addition to the …

Cadherins are essential adhesion proteins that regulate tissue cohesion and paracellular
permeability by assembling dense adhesion plaques at cell-to-cell contacts. Adherens …

Receptor tyrosine kinases (RTKs) are single-pass membrane proteins that control vital cell
processes such as cell growth, survival, and differentiation. There is a growing body of …