Antibiotic resistance in patients with cystic fibrosis: past, present, and future

EP Perikleous, D Gkentzi, A Bertzouanis, E Paraskakis… - Antibiotics, 2023 - mdpi.com
Patients with cystic fibrosis (CF) are repeatedly exposed to antibiotics, especially during the
pulmonary exacerbations of the disease. However, the available therapeutic strategies are …

Polymicrobial Interactions in the Cystic Fibrosis Airway Microbiome Impact the Antimicrobial Susceptibility of Pseudomonas aeruginosa

E Reece, PHA Bettio, J Renwick - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa is one of the most dominant pathogens in cystic fibrosis (CF)
airway disease and contributes to significant inflammation, airway damage, and poorer …

Lung function and microbiota diversity in cystic fibrosis

L Cuthbertson, AW Walker, AE Oliver, GB Rogers… - Microbiome, 2020 - Springer
Background Chronic infection and concomitant airway inflammation is the leading cause of
morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in …

Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children

MS Muhlebach, BT Zorn, CR Esther, JE Hatch… - PLoS …, 2018 - journals.plos.org
The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however,
little is known about its relationship to early disease progression. To better understand the …

Community dynamics and the lower airway microbiota in stable chronic obstructive pulmonary disease, smokers and healthy non-smokers

GG Einarsson, DM Comer, L McIlreavey, J Parkhill… - Thorax, 2016 - thorax.bmj.com
Rationale The role bacteria play in the progression of COPD has increasingly been
highlighted in recent years. However, the microbial community complexity in the lower …

The CF-Sputum Induction Trial (CF-SpIT) to assess lower airway bacterial sampling in young children with cystic fibrosis: a prospective internally controlled …

K Ronchetti, JD Tame, C Paisey, LP Thia… - The Lancet …, 2018 - thelancet.com
Background Pathogen surveillance is challenging but crucial in children with cystic fibrosis—
who are often non-productive of sputum even if actively coughing—because infection and …

Analysis of lung microbiota in bronchoalveolar lavage, protected brush and sputum samples from subjects with mild-to-moderate cystic fibrosis lung disease

DA Hogan, SD Willger, EL Dolben, TH Hampton… - PloS one, 2016 - journals.plos.org
Individuals with cystic fibrosis (CF) often acquire chronic lung infections that lead to
irreversible damage. We sought to examine regional variation in the microbial communities …

Fluctuations in airway bacterial communities associated with clinical states and disease stages in cystic fibrosis

LA Carmody, LJ Caverly, BK Foster, MAM Rogers… - PLoS …, 2018 - journals.plos.org
Bacteria that infect the airways of persons with cystic fibrosis (CF) include a group of well-
described opportunistic pathogens as well as numerous, mainly obligate or facultative …

Intestinal microbiota in patients with chronic hepatitis C with and without cirrhosis compared with healthy controls

B Heidrich, M Vital, I Plumeier, N Döscher… - Liver …, 2018 - Wiley Online Library
Abstract Background & Aims The importance of the intestinal microbiota for the onset and
clinical course of many diseases, including liver diseases like non‐alcoholic steatohepatitis …

Linking microbiota and respiratory disease

M Hauptmann, UE Schaible - FEBS letters, 2016 - Wiley Online Library
An increasing body of evidence indicates the relevance of microbiota for pulmonary health
and disease. Independent investigations recently demonstrated that the lung harbors a …