Antibiotic resistance in patients with cystic fibrosis: past, present, and future
EP Perikleous, D Gkentzi, A Bertzouanis, E Paraskakis… - Antibiotics, 2023 - mdpi.com
Patients with cystic fibrosis (CF) are repeatedly exposed to antibiotics, especially during the
pulmonary exacerbations of the disease. However, the available therapeutic strategies are …
pulmonary exacerbations of the disease. However, the available therapeutic strategies are …
Polymicrobial Interactions in the Cystic Fibrosis Airway Microbiome Impact the Antimicrobial Susceptibility of Pseudomonas aeruginosa
E Reece, PHA Bettio, J Renwick - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa is one of the most dominant pathogens in cystic fibrosis (CF)
airway disease and contributes to significant inflammation, airway damage, and poorer …
airway disease and contributes to significant inflammation, airway damage, and poorer …
Lung function and microbiota diversity in cystic fibrosis
Background Chronic infection and concomitant airway inflammation is the leading cause of
morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in …
morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in …
Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children
MS Muhlebach, BT Zorn, CR Esther, JE Hatch… - PLoS …, 2018 - journals.plos.org
The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however,
little is known about its relationship to early disease progression. To better understand the …
little is known about its relationship to early disease progression. To better understand the …
Community dynamics and the lower airway microbiota in stable chronic obstructive pulmonary disease, smokers and healthy non-smokers
GG Einarsson, DM Comer, L McIlreavey, J Parkhill… - Thorax, 2016 - thorax.bmj.com
Rationale The role bacteria play in the progression of COPD has increasingly been
highlighted in recent years. However, the microbial community complexity in the lower …
highlighted in recent years. However, the microbial community complexity in the lower …
The CF-Sputum Induction Trial (CF-SpIT) to assess lower airway bacterial sampling in young children with cystic fibrosis: a prospective internally controlled …
K Ronchetti, JD Tame, C Paisey, LP Thia… - The Lancet …, 2018 - thelancet.com
Background Pathogen surveillance is challenging but crucial in children with cystic fibrosis—
who are often non-productive of sputum even if actively coughing—because infection and …
who are often non-productive of sputum even if actively coughing—because infection and …
Analysis of lung microbiota in bronchoalveolar lavage, protected brush and sputum samples from subjects with mild-to-moderate cystic fibrosis lung disease
DA Hogan, SD Willger, EL Dolben, TH Hampton… - PloS one, 2016 - journals.plos.org
Individuals with cystic fibrosis (CF) often acquire chronic lung infections that lead to
irreversible damage. We sought to examine regional variation in the microbial communities …
irreversible damage. We sought to examine regional variation in the microbial communities …
Fluctuations in airway bacterial communities associated with clinical states and disease stages in cystic fibrosis
LA Carmody, LJ Caverly, BK Foster, MAM Rogers… - PLoS …, 2018 - journals.plos.org
Bacteria that infect the airways of persons with cystic fibrosis (CF) include a group of well-
described opportunistic pathogens as well as numerous, mainly obligate or facultative …
described opportunistic pathogens as well as numerous, mainly obligate or facultative …
Intestinal microbiota in patients with chronic hepatitis C with and without cirrhosis compared with healthy controls
B Heidrich, M Vital, I Plumeier, N Döscher… - Liver …, 2018 - Wiley Online Library
Abstract Background & Aims The importance of the intestinal microbiota for the onset and
clinical course of many diseases, including liver diseases like non‐alcoholic steatohepatitis …
clinical course of many diseases, including liver diseases like non‐alcoholic steatohepatitis …
Linking microbiota and respiratory disease
M Hauptmann, UE Schaible - FEBS letters, 2016 - Wiley Online Library
An increasing body of evidence indicates the relevance of microbiota for pulmonary health
and disease. Independent investigations recently demonstrated that the lung harbors a …
and disease. Independent investigations recently demonstrated that the lung harbors a …