Recent advances of tubulin inhibitors targeting the colchicine binding site for cancer therapy
M Hawash - Biomolecules, 2022 - mdpi.com
Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …
Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic …
S El-Kalyoubi, MM Khalifa, MT Abo-Elfadl… - Journal of enzyme …, 2023 - Taylor & Francis
A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …
Newly synthesized pyrazolinone chalcones as anticancer agents via inhibiting the PI3K/Akt/ERK1/2 signaling pathway
A series of novel pyrazolinone chalcones 3–9 have been synthesized through the
condensation of azo pyrazolinone derivatives with various aromatic aldehydes …
condensation of azo pyrazolinone derivatives with various aromatic aldehydes …
Structure–activity relationship studies based on quinazoline derivatives as EGFR kinase inhibitors (2017–present)
The epidermal growth factor receptor (EGFR) plays a critical role in the tumorigenesis of
various forms of cancer. Targeting the mutant forms of EGFR has been identified as an …
various forms of cancer. Targeting the mutant forms of EGFR has been identified as an …
Synthesis, in-vitro α-glucosidase inhibition and molecular docking studies of 1, 3, 4-thiadiazole-5, 6-diphenyl-1, 2, 4-triazine hybrids: potential leads in the search of …
Abstract A series of 1, 3, 4-thiadiazole-5, 6-diphenyl-triazine hybrids 7a-l have been
designed, synthesized and investigated for the α-glucosidase inhibitory activities. All the …
designed, synthesized and investigated for the α-glucosidase inhibitory activities. All the …
Construction of Highly Functionalized C4-Oxyacylated and Aminated Pyrazolines
Pyrazolines and pyrazolones are prevalent cores in drugs and bioactive molecules.
Functionalizing them with heteroatoms on the ring improves or expands their clinical …
Functionalizing them with heteroatoms on the ring improves or expands their clinical …
Synthesis, characterization, and DFT study of the s-triazine analogues of medicinal interest incorporated with five-and six-membered bioactive heterocyclic scaffolds
The present paper reports the synthesis, NMR study, and detailed computational
investigation of various novel s-triazine analogues 9–12 of medicinal interest embellished …
investigation of various novel s-triazine analogues 9–12 of medicinal interest embellished …
Density functional modeling, and molecular docking with SARS-CoV-2 spike protein (Wuhan) and omicron S protein (variant) studies of new heterocyclic compounds …
Nowadays, different vaccines and antiviral drugs have been developed and their
effectiveness has been proven against SARS-CoV-2. Pyrazoline derivatives are biologically …
effectiveness has been proven against SARS-CoV-2. Pyrazoline derivatives are biologically …
Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents: in silico study and …
H Pourtaher, Y Mohammadi, A Hasaninejad… - RSC Medicinal …, 2024 - pubs.rsc.org
Alzheimer's disease is a neurodegenerative disorder that impacts memory, thinking, and
behavior, and currently, there is no effective cure available for its treatment. This study …
behavior, and currently, there is no effective cure available for its treatment. This study …