Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose
tissue is generally linked to excessive body fat, and it is well known that the female breast is …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are involved in regulating glucose and lipid homeostasis, inflammation …

Pparg, a nuclear receptor, is downregulated in basal subtype bladder cancers that tend to
be muscle invasive and amplified in luminal subtype bladder cancers that tend to be non …

Type 2 diabetes is a serious health problem that affects more than 7% of adults in developed
countries. Up to 16% of patients with breast cancer have diabetes, and two major risk factors …

A characteristic feature of leukemia cells is a blockade of differentiation at a distinct stage in
cellular maturation. In the 1970s and 1980s, studies demonstrating the capabilities of certain …

The malignant neoplasm of the cervix, cervical cancer, has effects on the reproductive tract.
Although infection with oncogenic human papillomavirus is essential for cervical cancer …

Although peroxisome proliferator-activated receptor gamma (PPARγ) agonists such as
thiazolidinediones (TZDs) are widely used to treat type 2 diabetes, how its activation in …

Long-term usage of rosiglitazone, a synthetic PPARγ agonist, increases fracture rates
among diabetic patients. PPARγ suppresses osteoblastogenesis while activating …

The peroxisome proliferator–activated receptor-γ (PPAR-γ) is a nuclear receptor that is
activated by lipids to induce the expression of genes involved in lipid and glucose …